DENR–MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation
نویسندگان
چکیده
منابع مشابه
Constraints on reinitiation of translation in mammals.
The efficiency of reinitiation in mammalian translation systems depends in part on the size and arrangement of upstream open reading frames (upORFs). The gradual decrease in reinitiation as an upORF is lengthened, confirmed here using a variety of sequences, might reflect time-dependent loss of protein factors required for reinitiation. Consistent with the idea that the duration of elongation i...
متن کاملTruncated Channels by the Reinitiation of Translation
3 Matthew R. Stump, Qiuming Gong and Zhengfeng Zhou* 4 5 Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239 6 7 Running Title: Truncation of hERG PAS domain associated with LQT2 mutations 8 9 *Corresponding Author: Dr. Zhengfeng Zhou 10 Knight Cardiovascular Institute 11 Oregon Health & Science University 12 3181 SW Sam Jackson Park Road 13 Portland, OR ...
متن کاملPrimPol is required for replication reinitiation after mtDNA damage.
Eukaryotic PrimPol is a recently discovered DNA-dependent DNA primase and translesion synthesis DNA polymerase found in the nucleus and mitochondria. Although PrimPol has been shown to be required for repriming of stalled replication forks in the nucleus, its role in mitochondria has remained unresolved. Here we demonstrate in vivo and in vitro that PrimPol can reinitiate stalled mtDNA replicat...
متن کاملNudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
NudE and NudEL are related proteins that interact with cytoplasmic dynein and LIS1. Their functional relationship and involvement in LIS1 and dynein regulation are not completely understood. We find that NudE and NudEL each localize to mitotic kinetochores before dynein, dynactin, ZW10, and LIS1 and exhibit additional temporal and spatial differences in distribution from the motor protein. Inhi...
متن کاملIs tRNA binding or tRNA mimicry mandatory for translation factors?
tRNA is the adaptor in the translation process. The ribosome has three sites for tRNA, the A-, P-, and E-sites. The tRNAs bridge between the ribosomal subunits with the decoding site and the mRNA on the small or 30S subunit and the peptidyl transfer site on the large or 50S subunit. The possibility that translation release factors could mimic tRNA has been discussed for a long time, since their...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2018
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.2005160